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Patients on corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody responseCorticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccinesRoutine administration of vaccines or toxoids should be deferred until corticosteroid therapy is discontinued if possiblesee WARNINGSInfectionsVaccination

The dosage and length of treatment are based on your medical condition and response to therapyYour doctor may attempt to reduce your dose slowly from time to time to minimize side effects.

The following adverse reactions have been reported with dexamethasone or other corticosteroids:

EndocrineDecreased carbohydrate and glucose tolerancedevelopment of cushingoid statehyperglycemiaglycosuriahirsutismhypertrichosisincreased requirements for insulin or oral hypoglycemic agents in diabetesmanifestations of latent diabetes mellitusmenstrual irregularitiessecondary adrenocortical and pituitary unresponsivenessparticularly in times of stressas in traumasurgeryor illnesssuppression of growth in pediatric patients.

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