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Depo medrol is a corticosteroid designed to simulate a hormone that occurs in the cat s adrenal cortex.

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2Product InformationSolu-MedrolmethylprednisolonePharmaciaUpjohnKalamazooMI.

Along with its needed effectsmethylprednisolonethe active ingredient contained in Medrolmay cause some unwanted effectsAlthough not all of these side effects may occurif they do occur they may need medical attention.

Potentiated by CYP3A4 inhibitorsegketoconazolemacrolidescyclosporineestrogensAntagonized by CYP3A4 inducersegbarbituratesphenytoincarbamazepinerifampincholestyramineMay potentiate cyclosporineseizure riskMay antagonize oral anticoagulantsmonitorisoniazidIncreased risk of arrhythmias with digitalisMay need to adjust dose of antidiabetic agentsMonitor for hypokalemia with potassium-depleting drugsegamphotericin BdiureticsConcomitant neuromuscular blocking agentsincreased risk of myopathyWithdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapyAminoglutethimide may lead to loss of corticosteroid-induced adrenal suppressionIncreased GI effects with aspirinother NSAIDsCaution with aspirin in hypoprothrombinemiaMay suppress reactions to skin tests.

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