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The following adverse reactions have also been reported in neonates treated with indomethacin, however, a causal relationship to therapy with indocin i.

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When indomethacin is used in combination with methotrexateRheumatrexTrexallor aminoglycosidesfor examplegentamicinthe blood levels of the methotrexate or aminoglycoside may increasepresumably because their elimination from the body is reducedThis may lead to more methotrexate or aminoglycoside-related side effects.

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Nonsteroidal anti-inflammatory drugsincluding indomethacinmay rarely increase the risk for a heart attack or strokeThis effect can happen at any time while taking this drug but is more likely if you take it for a long timeThe risk may be greater if you have heart disease or increased risk for heart diseasefor exampledue to smokingfamily history of heart diseaseor conditions such as high blood pressure or diabetesDo not take this drug right before or after heart bypass surgeryCABG

Indomethacin should be avoided by patients with a history of asthma attackshives or other allergic reactions to aspirin or other NSAIDs.

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