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InfrequentAkathisiaapathyaphasiacentral nervous system depressiondepersonalizationdysarthriadyskinesiaeuphoriahallucinationshostilityhyperkinesiahypertonialibido decreasedmemory decreasemind racingmovement disordermyoclonuspanic attackparanoid reactionpersonality disorderpsychosissleep disorderstuporsuicidal ideation.
The first sign of any skin rashno matter how mildfeverswollen glandsbody achesflu symptomsheadacheneck stiffnessincreased sensitivity to lighteasy bruising or bleedingsevere tinglingnumbnesspainmuscle weaknessupper stomach painloss of appetitedark urinejaundiceyellowing of the skin or eyeschest painirregular heart rhythmfeeling short of breathconfusionnausea and vomitingswellingrapid weight gainurinating less than usual or not at allpale skinfeeling light-headed or short of breathrapid heart ratetrouble concentratingor increased seizures or worsening of your bipolar disorder.
RECOMMENDATIONHealthcare professionals should be aware that prompt recognition and early treatment is important for improving HLH outcomes and decreasing mortalityDiagnosis is often complicated because early signs and symptoms such as fever and rash are not specificHLH may also be confused with other serious immune-related adverse reactions such as Drug Reaction with Eosinophilia and Systemic SymptomsDRESS
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