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Initially 12g m 2 iv infusion over 4 hours; may be increased to 15g m 2 ; see literature for leucovorin rescue dosing with high-dose methotrexate.

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This medication may lower your ability to fight infectionsThis may make you more likely to get a seriousrarely fatalinfection or make any infection you have worseTell your doctor right away if you have any signs of infectionsuch as feverchillspersistent sore throatcough

To lower the chance of getting cutbruisedor injureduse caution with sharp objects like razors and nail cuttersand avoid activities such as contact sports.

If you need to be sedated for dental worktell your dentist you currently use this medicine.

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