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No specific antidote for cyclophosphamide is knownOverdosage should be managed with supportive measuresincluding appropriate treatment for any concurrent infectionmyelosuppressionor cardiac toxicity should it occur.

Jay WMarksMDis a board-certified internist and gastroenterologistHe graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

When cyclophosphamide is included in combined cytotoxic regimensit may be necessary to reduce the dose of cyclophosphamide as well as that of the other drugs.

Risk of potentially fatal and irreversible interstitial pulmonary fibrosis if given over prolonged periods.

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