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Reglan, a heartburn, nausea and gastric paresis medicine, is alleged to have caused extremely serious side effects .

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The antiemetic properties of metoclopramide appear to be a result of its antagonism of central and peripheral dopamine receptorsDopamine produces nausea and vomiting by stimulation of the medullary chemoreceptor trigger zoneCTZand metoclopramide blocks stimulation of the CTZ by agents like ldopa or apomorphine which are known to increase dopamine levels or to possess dopamine-like effectsMetoclopramide also abolishes the slowing of gastric emptying caused by apomorphine.

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This medication is used to treat certain conditions of the stomach and intestinesMetoclopramide is used as a short-term treatment4 to 12 weeksfor persistent heartburn when the usual medicines do not work well enoughIt is used mostly for heartburn that occurs after a meal or during the daytimeTreating persistent heartburn can decrease the damage done by stomach acid to the swallowing tubeesophagusand help healing.

Metoclopramide increases the tone and amplitude of gastricespecially antralcontractionsrelaxes the pyloric sphincter and the duodenal bulband increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transitIt increases the resting tone of the lower esophageal sphincterIt has littleif anyeffect on the motility of the colon or gallbladder.

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do not drink alcohol while receiving reglan.